Oxymorphone Extended-Release

Opana ERâ„¢

What It's For & How To Take

Oxymorphone extended-release is used to treat severe ongoing pain. This medication is an opiate, and it works in the brain to block how the body recognizes pain.

Oxymorphone extended-release is taken on a scheduled basis and is not for occasional or as needed use. It is usually prescribed to be taken 2 times daily, or as directed by your doctor. This medication is taken either 1 hour before or 2 hours after a meal. If you take this medication with food, your body may absorb the medication too quickly and lead to increased side effects. Swallow the tablet whole, do not crush or chew the tablet.

If you miss a dose, take it as soon as you remember. If it is near the time of your next dose, skip it and continue with your normal dose time. Do not take a double dose to make up the missed dose.

Your doctor may prescribe a short-acting pain medication to be taken with your oxymorphone extended-release. This medication is used for sudden or sharp pain that flares up during certain times of the day.

Tell your doctor if your pain is not getting better. Your dose is based on your current condition and may need to be changed as your condition changes. Do not stop taking this medication suddenly because you may feel uncomfortable withdrawal symptoms such as muscle aches, sweating, nausea, and vomiting. Your doctor may decrease your dose over a time to decrease the withdrawal symptoms.

Most Important Warnings

  • Oxymorphone extended release is only for moderate to severe pain when around the clock pain control is needed and other pain medications are not working.
  • If this medication is used on a patient not used to taking narcotics, they may stop breathing. Serious or fatal cases have happened even with the regular dose. Swallow the tablet whole, do not crush or chew the tablet.
  • This medication has an increased risk of abuse, addiction, and theft. Let your doctor know if you or anyone in your family has a history of substance abuse. Store this medication in a safe place to prevent theft.
  • If a child accidentally takes even one tablet, they may stop breathing and die.
  • When pregnant mothers use this medication, the unborn child is at risk. The newborn may need prolonged withdrawal treatment.
  • This medication may interact with other specific medications and cause serious side effects including death. Tell your doctor and pharmacist all your other medications before starting oxymorphone extended release.
  • Combining this medication with anxiety medications, such as diazepam or alprazolam, may cause extreme sleepiness, significant breathing difficulties, and death.

Warnings & Cautions

  • Rarely, this medication may cause a drug seeking or addictive behavior. This risk is increased if you have a history of alcohol or drug abuse. If you follow the directions on the label and stay in good communication with your doctor and pharmacist, the chances for addiction are lower.
  • The elderly may be more sensitive to the side effects of this medication, especially the drowsiness, dizziness, constipation and urinary problems.
  • Do not drive or do any activity that requires focus and attention until you are sure you can do them safely. Avoid alcoholic beverages while using oxymorphone extended release.
  • Infants born to mothers who are using this medication are at risk. This medication should only be used during pregnancy when the benefit to the mother is greater than the risk to the unborn baby.
  • Oxymorphone extended-release passes into breast milk. Breastfeeding is not recommended while using this medication.

Interactions & Side Effects

  • Tell your pharmacist or doctor all your medication allergies so they may determine if oxymorphone extended release is safe for you to use.
  • Avoid dangerous drug interactions. Tell your pharmacist or doctor all the other medication you are taking, including over the counter supplements, even if you don't take them very often.
  • Ask your doctor if this medication is safe to take with your current health conditions. Tell your doctor if you have a slow bowel, chronic constipation, seizures, slow heartbeat, trouble urinating, low blood pressure, a family history of substance abuse or any other disease you have a history of.
  • While using oxymorphone extended-release, you may feel some nausea, vomiting, dizziness, drowsiness or constipation. If these or any other unwanted side effects persist, contact your doctor or pharmacist to talk about it with them.
  • Constipation may be a problem when this medication is used. Talk with your pharmacist about what would work best for you to keep your bowels moving.
  • Call your doctor right away if you have any heartbeat changes, hallucinations, seizure, loss of coordination or any other significant side effects.
  • Call emergency 911 if you have any difficulty breathing.
If you have any questions about what you have heard, contact your pharmacist or doctor. This session does not include all the potential interactions or side effects that this medication may cause. Ask your pharmacist how your medication should be stored and how you should dispose of it when you are done taking it. Do not share your medication with anyone, ever. Remember, this is not meant to replace your counseling session with your pharmacist. In case of overdose, call your local poison control center at 1-800-222-1222.